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Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the U(L)47 tegument protein

Herpes simplex virus 1 (HSV-1) encodes an endoribonuclease that is responsible for the shutoff of host protein synthesis [virion host shutoff (VHS)-RNase]. The VHS-RNase released into cells during infection targets differentially four classes of mRNAs. Thus, (a) VHS-RNase degrades stable cellular mR...

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Bibliografiset tiedot
Päätekijät: Shu, Minfeng, Taddeo, Brunella, Zhang, Weiran, Roizman, Bernard
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645526/
https://ncbi.nlm.nih.gov/pubmed/23589852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305475110
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