Chimeric Exchange of Coronavirus nsp5 Proteases (3CLpro) Identifies Common and Divergent Regulatory Determinants of Protease Activity

Human coronaviruses (CoVs) such as severe acute respiratory syndrome CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV) cause epidemics of severe human respiratory disease. A conserved step of CoV replication is the translation and processing of replicase polyproteins containing 16 n...

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Hauptverfasser: Stobart, Christopher C., Sexton, Nicole R., Munjal, Havisha, Lu, Xiaotao, Molland, Katrina L., Tomar, Sakshi, Mesecar, Andrew D., Denison, Mark R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838113/
https://ncbi.nlm.nih.gov/pubmed/24027335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02050-13
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