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Exchange of the Coronavirus Replicase Polyprotein Cleavage Sites Alters Protease Specificity and Processing
Coronavirus nonstructural proteins 1 to 3 are processed by one or two papain-like proteases (PLP1 and PLP2) at specific cleavage sites (CS1 to -3). Murine hepatitis virus (MHV) PLP2 and orthologs recognize and cleave at a position following a p4-Leu-X-Gly-Gly-p1 tetrapeptide, but it is unknown wheth...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903247/ https://ncbi.nlm.nih.gov/pubmed/20427532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00752-10 |
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