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Exchange of the Coronavirus Replicase Polyprotein Cleavage Sites Alters Protease Specificity and Processing

Coronavirus nonstructural proteins 1 to 3 are processed by one or two papain-like proteases (PLP1 and PLP2) at specific cleavage sites (CS1 to -3). Murine hepatitis virus (MHV) PLP2 and orthologs recognize and cleave at a position following a p4-Leu-X-Gly-Gly-p1 tetrapeptide, but it is unknown wheth...

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Bibliografski detalji
Glavni autori: Gadlage, Mark J., Denison, Mark R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903247/
https://ncbi.nlm.nih.gov/pubmed/20427532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00752-10
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