Biological Evaluation of Benzothiazole Ethyl Urea Inhibitors of Bacterial Type II Topoisomerases

The type II topoisomerases DNA gyrase (GyrA/GyrB) and topoisomerase IV (ParC/ParE) are well-validated targets for antibacterial drug discovery. Because of their structural and functional homology, these enzymes are amenable to dual targeting by a single ligand. In this study, two novel benzothiazole...

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Bibliographic Details
Main Authors: Stokes, Neil R., Thomaides-Brears, Helena B., Barker, Stephanie, Bennett, James M., Berry, Joanne, Collins, Ian, Czaplewski, Lloyd G., Gamble, Vicki, Lancett, Paul, Logan, Alastair, Lunniss, Christopher J., Peasley, Hilary, Pommier, Stéphanie, Price, Daniel, Smee, Carol, Haydon, David J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837865/
https://ncbi.nlm.nih.gov/pubmed/24041906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00719-13
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