Biological Evaluation of Benzothiazole Ethyl Urea Inhibitors of Bacterial Type II Topoisomerases

The type II topoisomerases DNA gyrase (GyrA/GyrB) and topoisomerase IV (ParC/ParE) are well-validated targets for antibacterial drug discovery. Because of their structural and functional homology, these enzymes are amenable to dual targeting by a single ligand. In this study, two novel benzothiazole...

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Detalhes bibliográficos
Main Authors: Stokes, Neil R., Thomaides-Brears, Helena B., Barker, Stephanie, Bennett, James M., Berry, Joanne, Collins, Ian, Czaplewski, Lloyd G., Gamble, Vicki, Lancett, Paul, Logan, Alastair, Lunniss, Christopher J., Peasley, Hilary, Pommier, Stéphanie, Price, Daniel, Smee, Carol, Haydon, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837865/
https://ncbi.nlm.nih.gov/pubmed/24041906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00719-13
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