Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin

The platelet protein disulfide isomerase called ERp57 mediates platelet aggregation, but its role in thrombus formation is unknown. To determine the specific role of platelet-derived ERp57 in hemostasis and thrombosis, we generated a megakaryocyte/platelet-specific knockout. Despite normal platelet...

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Autors principals: Wang, Lu, Wu, Yi, Zhou, Junsong, Ahmad, Syed S., Mutus, Bulent, Garbi, Natalio, Hämmerling, Günter, Liu, Junling, Essex, David W.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2013
Matèries:
Platelets and Thrombopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837513/
https://ncbi.nlm.nih.gov/pubmed/24030382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-06-506691
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