Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin

The platelet protein disulfide isomerase called ERp57 mediates platelet aggregation, but its role in thrombus formation is unknown. To determine the specific role of platelet-derived ERp57 in hemostasis and thrombosis, we generated a megakaryocyte/platelet-specific knockout. Despite normal platelet...

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Detalhes bibliográficos
Main Authors: Wang, Lu, Wu, Yi, Zhou, Junsong, Ahmad, Syed S., Mutus, Bulent, Garbi, Natalio, Hämmerling, Günter, Liu, Junling, Essex, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837513/
https://ncbi.nlm.nih.gov/pubmed/24030382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-06-506691
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