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Molecular Modeling of Inhibitors of Human DNA Methyltransferase with a Crystal Structure: Discovery of a Novel DNMT1 Inhibitor

DNA methyltransferases (DNMTs) are promising epigenetic targets for the development of novel anticancer drugs and other diseases. Molecular modeling and experimental approaches are being used to identify and develop inhibitors of human DNMTs. Most of the computational efforts conducted so far with D...

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書誌詳細
主要な著者: Yoo, Jakyung, Kim, Joo Hee, Robertson, Keith D., Medina-Franco, José L.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier Inc. 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837394/
https://ncbi.nlm.nih.gov/pubmed/22607757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-398312-1.00008-1
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