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Molecular Modeling of Inhibitors of Human DNA Methyltransferase with a Crystal Structure: Discovery of a Novel DNMT1 Inhibitor

DNA methyltransferases (DNMTs) are promising epigenetic targets for the development of novel anticancer drugs and other diseases. Molecular modeling and experimental approaches are being used to identify and develop inhibitors of human DNMTs. Most of the computational efforts conducted so far with D...

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Bibliografiske detaljer
Main Authors: Yoo, Jakyung, Kim, Joo Hee, Robertson, Keith D., Medina-Franco, José L.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Inc. 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837394/
https://ncbi.nlm.nih.gov/pubmed/22607757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-398312-1.00008-1
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