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Insulin Secretion and Ca(2+) Dynamics in β-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) (EIF2AK3) is essential for normal development and function of the insulin-secreting β-cell. Although genetic ablation of PERK in β-cells results in permanent neonatal diabetes in humans and mice, the underlying mechanisms remain unclear...

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Bibliografische gegevens
Hoofdauteurs: Wang, Rong, McGrath, Barbara C., Kopp, Richard F., Roe, Michael W., Tang, Xin, Chen, Gong, Cavener, Douglas R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837125/
https://ncbi.nlm.nih.gov/pubmed/24114838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503664
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