The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones

Loss-of-function mutations of the protein kinase PERK (EIF2AK3) in humans and mice cause permanent neonatal diabetes and severe proinsulin aggregation in the endoplasmic reticulum (ER), highlighting the essential role of PERK in insulin production in pancreatic β cells. As PERK is generally known as...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sowers, Carrie R., Wang, Rong, Bourne, Rebecca A., McGrath, Barbara C., Hu, Jingjie, Bevilacqua, Sarah C., Paton, James C., Paton, Adrienne W., Collardeau-Frachon, Sophie, Nicolino, Marc, Cavener, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892574/
https://ncbi.nlm.nih.gov/pubmed/29444822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813790
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