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Intracellular localization of 125I-labeled insulin in hepatocytes from intact rat liver.

We have shown that 125I-labeled insulin initially localizes to the plasma membrane of isolated rat hepatocytes. The ligand is subsequently internalized and preferentially localizes to lysosomal structures. Further, we have observed that labeled insulin localizes to regions of the cell rich in lysoso...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Carpentier, J L, Gorden, P, Barazzone, P, Freychet, P, Le Cam, A, Orci, L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1979
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383697/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/288068/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.6.2803
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