Intracellular localization of 125I-labeled insulin in hepatocytes from intact rat liver.

We have shown that 125I-labeled insulin initially localizes to the plasma membrane of isolated rat hepatocytes. The ligand is subsequently internalized and preferentially localizes to lysosomal structures. Further, we have observed that labeled insulin localizes to regions of the cell rich in lysoso...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Carpentier, J L, Gorden, P, Barazzone, P, Freychet, P, Le Cam, A, Orci, L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1979
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383697/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/288068/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.6.2803
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