Intracellular localization of 125I-labeled insulin in hepatocytes from intact rat liver.

We have shown that 125I-labeled insulin initially localizes to the plasma membrane of isolated rat hepatocytes. The ligand is subsequently internalized and preferentially localizes to lysosomal structures. Further, we have observed that labeled insulin localizes to regions of the cell rich in lysoso...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Carpentier, J L, Gorden, P, Barazzone, P, Freychet, P, Le Cam, A, Orci, L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1979
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383697/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/288068/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.6.2803
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