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Reconstitution of R-spondin:LGR4:ZNRF3 Adult Stem Cell Growth Factor Signaling Complexes with Recombinant Proteins Produced in E. coli
R-spondins are secreted glycoproteins (RSPO1, -2, -3, and -4) that exhibit proliferative effects on adult stem cells by potentiating Wnt signaling. RSPO actions are mediated by the leucine rich repeat (LRR)-containing 7-TM receptors LGR4, -5, and -6 and the transmembrane E3 ubiquitin ligases ZNRF3 a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3836688/ https://ncbi.nlm.nih.gov/pubmed/24050775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401090h |
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