Molecular Pharmacology and Ligand Docking Studies Reveal a Single Amino Acid Difference between Mouse and Human Serotonin 5-HT2A Receptors That Impacts Behavioral Translation of Novel 4-Phenyl-2-dimethylaminotetralin Ligands

During translational studies to develop 4-phenyl-2-dimethylaminotetralin (PAT) compounds for neuropsychiatric disorders, the (2R,4S)-trans-(+)- and (2S,4R)-trans-(−)-enantiomers of the analog 6-hydroxy-7-chloro-PAT (6-OH-7-Cl-PAT) demonstrated unusual pharmacology at serotonin (5-HT) 5-HT2 G protein...

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Bibliographic Details
Main Authors: Canal, Clinton E., Cordova-Sintjago, Tania, Liu, Yue, Kim, Myong S., Morgan, Drake, Booth, Raymond G.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
Subjects:
Drug Discovery and Translational Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836315/
https://ncbi.nlm.nih.gov/pubmed/24080681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.208637
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