Completely Humanizing Prolactin Rescues Infertility in Prolactin Knockout Mice and Leads to Human Prolactin Expression in Extrapituitary Mouse Tissues

A variety of fundamental differences have evolved in the physiology of the human and rodent prolactin (PRL) systems. The PRL gene in humans and other primates contains an alternative promoter, 5.8 kbp upstream of the pituitary transcription start site, which drives expression of PRL in “extrapituita...

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書誌詳細
主要な著者: Christensen, Heather R., Murawsky, Michael K., Horseman, Nelson D., Willson, Tara A., Gregerson, Karen A.
フォーマット: Artigo
言語:Inglês
出版事項: Endocrine Society 2013
主題:
Reproduction-Development
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836079/
https://ncbi.nlm.nih.gov/pubmed/24029242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1476
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