Completely Humanizing Prolactin Rescues Infertility in Prolactin Knockout Mice and Leads to Human Prolactin Expression in Extrapituitary Mouse Tissues

A variety of fundamental differences have evolved in the physiology of the human and rodent prolactin (PRL) systems. The PRL gene in humans and other primates contains an alternative promoter, 5.8 kbp upstream of the pituitary transcription start site, which drives expression of PRL in “extrapituita...

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Detalhes bibliográficos
Main Authors: Christensen, Heather R., Murawsky, Michael K., Horseman, Nelson D., Willson, Tara A., Gregerson, Karen A.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Reproduction-Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836079/
https://ncbi.nlm.nih.gov/pubmed/24029242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1476
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