Abnormal Calcium Cycling and Cardiac Arrhythmias Associated With the Human Ser96Ala Genetic Variant of Histidine‐Rich Calcium‐Binding Protein

BACKGROUND: A human genetic variant (Ser96Ala) in the sarcoplasmic reticulum (SR) histidine‐rich Ca(2+)‐binding (HRC) protein has been linked to ventricular arrhythmia and sudden death in dilated cardiomyopathy. However, the precise mechanisms affecting SR function and leading to arrhythmias remain...

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Bibliografiske detaljer
Main Authors: Singh, Vivek P., Rubinstein, Jack, Arvanitis, Demetrios A., Ren, Xiaoping, Gao, Xiaoqian, Haghighi, Kobra, Gilbert, Mark, Iyer, Venkat R., Kim, Do Han, Cho, Chunghee, Jones, Keith, Lorenz, John N., Armstrong, Clara F., Wang, Hong‐Sheng, Gyorke, Sandor, Kranias, Evangelia G.
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835262/
https://ncbi.nlm.nih.gov/pubmed/24125847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000460
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