Abnormal Calcium Cycling and Cardiac Arrhythmias Associated With the Human Ser96Ala Genetic Variant of Histidine‐Rich Calcium‐Binding Protein

BACKGROUND: A human genetic variant (Ser96Ala) in the sarcoplasmic reticulum (SR) histidine‐rich Ca(2+)‐binding (HRC) protein has been linked to ventricular arrhythmia and sudden death in dilated cardiomyopathy. However, the precise mechanisms affecting SR function and leading to arrhythmias remain...

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Detalhes bibliográficos
Main Authors: Singh, Vivek P., Rubinstein, Jack, Arvanitis, Demetrios A., Ren, Xiaoping, Gao, Xiaoqian, Haghighi, Kobra, Gilbert, Mark, Iyer, Venkat R., Kim, Do Han, Cho, Chunghee, Jones, Keith, Lorenz, John N., Armstrong, Clara F., Wang, Hong‐Sheng, Gyorke, Sandor, Kranias, Evangelia G.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835262/
https://ncbi.nlm.nih.gov/pubmed/24125847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000460
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