Abnormal Calcium Cycling and Cardiac Arrhythmias Associated With the Human Ser96Ala Genetic Variant of Histidine‐Rich Calcium‐Binding Protein

BACKGROUND: A human genetic variant (Ser96Ala) in the sarcoplasmic reticulum (SR) histidine‐rich Ca(2+)‐binding (HRC) protein has been linked to ventricular arrhythmia and sudden death in dilated cardiomyopathy. However, the precise mechanisms affecting SR function and leading to arrhythmias remain...

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Main Authors: Singh, Vivek P., Rubinstein, Jack, Arvanitis, Demetrios A., Ren, Xiaoping, Gao, Xiaoqian, Haghighi, Kobra, Gilbert, Mark, Iyer, Venkat R., Kim, Do Han, Cho, Chunghee, Jones, Keith, Lorenz, John N., Armstrong, Clara F., Wang, Hong‐Sheng, Gyorke, Sandor, Kranias, Evangelia G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Blackwell Publishing Ltd 2013
Ábhair:
Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835262/
https://ncbi.nlm.nih.gov/pubmed/24125847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000460
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