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Endosomolytic anionic polymer for the cytoplasmic delivery of siRNAs in localized in vivo applications
The use of small interfering RNAs (siRNAs) to down-regulate the expression of disease-associated proteins carries significant promise for the treatment of a variety of clinical disorders. One of the main barriers to the widespread clinical use of siRNAs, however, is their entrapment and degradation...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3834980/ https://ncbi.nlm.nih.gov/pubmed/24273480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adfm.201201945 |
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