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Endosomolytic anionic polymer for the cytoplasmic delivery of siRNAs in localized in vivo applications

The use of small interfering RNAs (siRNAs) to down-regulate the expression of disease-associated proteins carries significant promise for the treatment of a variety of clinical disorders. One of the main barriers to the widespread clinical use of siRNAs, however, is their entrapment and degradation...

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Autori principali: Khormaee, Sariah, Choi, Yong, Shen, Michael J., Xu, Biying, Wu, Haitao, Griffiths, Gary L., Chen, Rongjun, Slater, Nigel K. H., Park, John K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834980/
https://ncbi.nlm.nih.gov/pubmed/24273480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adfm.201201945
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