Chronic activation of the low affinity site of β(1)-adrenoceptors stimulates haemodynamics but exacerbates pressure-overload cardiac remodelling

BACKGROUND AND PURPOSE: The β(1)-adrenoceptor has at least two binding sites, high and low affinity sites (β(1H) and β(1L), respectively), which mediate cardiostimulation. While β(1H)-adrenoceptor can be blocked by all clinically used β-blockers, β(1L)-adrenoceptor is relatively resistant to blockad...

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Detalhes bibliográficos
Main Authors: Kiriazis, Helen, Tugiono, Niquita, Xu, Qi, Gao, Xiao-Ming, Jennings, Nicole L, Ming, Ziqui, Su, Yidan, Klenowski, Paul, Summers, Roger J, Kaumann, Alberto, Molenaar, Peter, Du, Xiao-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834759/
https://ncbi.nlm.nih.gov/pubmed/23750586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12272
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