Inhibition of Hedgehog and Androgen receptor signaling pathways produced synergistic suppression of castration-resistant prostate cancer progression

Metastatic prostate cancer (PCa) is initially treated with androgen ablation therapy, which causes regression of androgen-dependent tumors. However, these tumors eventually relapse resulting in recurrent castration-resistant prostate cancer (CRPC). Currently, there is no effective therapy for CRPC a...

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Hauptverfasser: Gowda, Pramod S., Deng, Jianhong D., Mishra, Sweta, Bandyopadhyay, Abhik, Liang, Sitai, Lin, Shu, Mahalingam, Devalingam, Sun, Lu-Zhe
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834015/
https://ncbi.nlm.nih.gov/pubmed/23989930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0278
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