Metformin Inhibits Expression and Secretion of PEDF in Adipocyte and Hepatocyte via Promoting AMPK Phosphorylation

Objective. Pigment epithelium-derived factor (PEDF) plays an important role in obesity-induced insulin resistance (IR). The study aims to investigate the effect of metformin, a widely used agent to improve IR, on PEDF production both in vivo and in vitro. Methods. SD rats were divided into normal co...

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Main Authors: Yang, Shumin, Lv, Qiong, Luo, Ting, Liu, Lulu, Gao, Rufei, Chen, Shumei, Ye, Peng, Cheng, Qingfeng, Li, Qifu
格式: Artigo
語言:Inglês
出版: Hindawi Publishing Corporation 2013
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833404/
https://ncbi.nlm.nih.gov/pubmed/24288442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/429207
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