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AMPK is not required for the effect of metformin on the inhibition of BMP6-induced hepcidin gene expression in hepatocytes

The biguanide metformin is used for its antidiabetic effect for many years but how metformin acts remains poorly understood and controversial. AMP-activated protein kinase (AMPK), a protein kinase that plays a key role in maintaining energy homeostasis, is assumed to be one of the prime targets of m...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Deschemin, Jean-Christophe, Foretz, Marc, Viollet, Benoit, Vaulont, Sophie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627262/
https://ncbi.nlm.nih.gov/pubmed/28978947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12976-2
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