Testing the Substrate-Envelope Hypothesis with Designed Pairs of Compounds

[Image: see text] Acquired resistance to therapeutic agents is a significant barrier to the development of clinically effective treatments for diseases in which evolution occurs on clinical time scales, frequently arising from target mutations. We previously reported a general strategy to design eff...

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Главные авторы: Shen, Yang, Altman, Michael D., Ali, Akbar, Nalam, Madhavi N. L., Cao, Hong, Rana, Tariq M., Schiffer, Celia A., Tidor, Bruce
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2013
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833293/
https://ncbi.nlm.nih.gov/pubmed/23952265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400468c
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