Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain

BACKGROUND: STAT3 is a transcription factor of central importance in chronic inflammation and cancer. In response to cytokine stimulation STAT3 is phosphorylated on a single tyrosine residue at position 705, dimerizes and accumulates in the nucleus to induce target gene expression. The substitution...

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Bibliographic Details
Main Authors: Mohr, Anne, Fahrenkamp, Dirk, Rinis, Natalie, Müller-Newen, Gerhard
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833267/
https://ncbi.nlm.nih.gov/pubmed/24192293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-83
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