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Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies
BACKGROUND: Short in-frame deletions in the second extracellular domain of the cytokine receptor gp130 are the leading cause of inflammatory hepatocellular adenomas (IHCAs). The deletions render gp130 constitutively active. In this study we investigate the intracellular signaling potential of one of...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007646/ https://ncbi.nlm.nih.gov/pubmed/24612692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-12-14 |
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