Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL

BACKGROUND: Tumour cell-selective activation of apoptosis by recombinant human TNF-related apoptosis-inducing ligand (rhTRAIL) is enhanced through co-activation of p53 by chemotherapeutic drugs. The novel anticancer agent nutlin-3 provides a promising alternative for p53 activation by disrupting the...

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Главные авторы: Meijer, A, Kruyt, F A E, van der Zee, A G J, Hollema, H, Le, P, ten Hoor, K A, Groothuis, G M M, Quax, W J, de Vries, E G E, de Jong, S
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2013
Предметы:
Molecular Diagnostics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833221/
https://ncbi.nlm.nih.gov/pubmed/24136147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.636
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