CD4(+) T Cell-Receptor Repertoire Diversity is Compromised in the Spleen but Not in the Bone Marrow of Aged Mice Due to Private and Sporadic Clonal Expansions

Reduction in T cell receptor (TCR) diversity in old age is considered as a major cause for immune complications in the elderly population. Here, we explored the consequences of aging on the TCR repertoire in mice using high-throughput sequencing (TCR-seq). We mapped the TCRβ repertoire of CD4+ T cel...

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Bibliographische Detailangaben
Hauptverfasser: Shifrut, Eric, Baruch, Kuti, Gal, Hilah, Ndifon, Wilfred, Deczkowska, Aleksandra, Schwartz, Michal, Friedman, Nir
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2013
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832891/
https://ncbi.nlm.nih.gov/pubmed/24312094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00379
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