Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures.

Partially purified extracts of bovine brain were previously found to inhibit competitively the binding of [3H]-diazepam to rat brain synaptosomal membranes. The purines inosine and hypoxanthine were subsequently identified as the compounds responsible for this inhibitory activity. Intracerebroventri...

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Main Authors: Skolnick, P, Syapin, P J, Paugh, B A, Moncada, V, Marangos, P J, Paul, S M
Format: Artigo
Jezik:Inglês
Izdano: 1979
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC383285/
https://ncbi.nlm.nih.gov/pubmed/286337
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