Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures.

Partially purified extracts of bovine brain were previously found to inhibit competitively the binding of [3H]-diazepam to rat brain synaptosomal membranes. The purines inosine and hypoxanthine were subsequently identified as the compounds responsible for this inhibitory activity. Intracerebroventri...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Skolnick, P, Syapin, P J, Paugh, B A, Moncada, V, Marangos, P J, Paul, S M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1979
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC383285/
https://ncbi.nlm.nih.gov/pubmed/286337
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi