Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures.

Partially purified extracts of bovine brain were previously found to inhibit competitively the binding of [3H]-diazepam to rat brain synaptosomal membranes. The purines inosine and hypoxanthine were subsequently identified as the compounds responsible for this inhibitory activity. Intracerebroventri...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Skolnick, P, Syapin, P J, Paugh, B A, Moncada, V, Marangos, P J, Paul, S M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1979
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/286337/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.3.1515
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