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Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures.

Partially purified extracts of bovine brain were previously found to inhibit competitively the binding of [3H]-diazepam to rat brain synaptosomal membranes. The purines inosine and hypoxanthine were subsequently identified as the compounds responsible for this inhibitory activity. Intracerebroventri...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Skolnick, P, Syapin, P J, Paugh, B A, Moncada, V, Marangos, P J, Paul, S M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1979
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383285/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/286337/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.3.1515
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