Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways

Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of hypoxia-inducible factor (HIF) and nuclear factor κB (NF-κB), both of which can regulate the inflammatory response. Furthermore, pharmac...

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Detalhes bibliográficos
Main Authors: Scholz, Carsten C., Cavadas, Miguel A. S., Tambuwala, Murtaza M., Hams, Emily, Rodríguez, Javier, von Kriegsheim, Alex, Cotter, Philip, Bruning, Ulrike, Fallon, Padraic G., Cheong, Alex, Cummins, Eoin P., Taylor, Cormac T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832034/
https://ncbi.nlm.nih.gov/pubmed/24145445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309718110
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