The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells

Localized tissue hypoxia is a feature of infection and inflammation, resulting in the upregulation of the transcription factors HIF-1α and NF-κB via inhibition of oxygen sensing hydroxylase enzymes. Previous studies have demonstrated a beneficial role for the hydroxylase inhibitor dimethyloxallyl gl...

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Autori principali: Hams, Emily, Saunders, Sean P., Cummins, Eoin P., O’Connor, Aisling, Tambuwala, Murtaza T., Gallagher, William M., Byrne, Annette, Campos-Torres, Antonio, Moynagh, Paul M., Jobin, Christian, Taylor, Cormac T., Fallon, Padraic G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157050/
https://ncbi.nlm.nih.gov/pubmed/21844787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0b013e318225ad7e
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