Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase

Sustained activation of N-methyl-d-aspartate (NMDA) -type glutamate receptors leads to excitotoxic neuronal death in stroke, brain trauma, and neurodegenerative disorders. Superoxide production by NADPH oxidase is a requisite event in the process leading from NMDA receptor activation to excitotoxic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lam, Tina I., Brennan-Minnella, Angela M., Won, Seok Joon, Shen, Yiguo, Hefner, Colleen, Shi, Yejie, Sun, Dandan, Swanson, Raymond A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2013
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832003/
https://ncbi.nlm.nih.gov/pubmed/24163350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313029110
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