Prolonged inhibition of 5-HT(3) receptors by palonosetron results from surface receptor inhibition rather than inducing receptor internalization

BACKGROUND AND PURPOSE: The 5-HT(3) receptor antagonist palonosetron is an important treatment for emesis and nausea during cancer therapy. Its clinical efficacy may result from its unique binding and clearance characteristics and receptor down-regulation mechanisms. We investigated the mechanisms b...

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Detaylı Bibliyografya
Asıl Yazarlar: Hothersall, J Daniel, Moffat, Christopher, Connolly, Christopher N
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Publishing Ltd 2013
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831706/
https://ncbi.nlm.nih.gov/pubmed/23581504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12204
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