Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT(1B) rather than 5-HT(1D) receptors

BACKGROUND AND PURPOSE: It has been suggested that during a migraine attack capsaicin-sensitive trigeminal sensory nerves release calcitonin gene-related peptide (CGRP), resulting in cranial vasodilatation and central nociception; hence, trigeminal inhibition may prevent this vasodilatation and abor...

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Main Authors: Muñoz-Islas, E, Gupta, S, Jiménez-Mena, L R, Lozano-Cuenca, J, Sánchez-López, A, Centurión, D, Mehrotra, S, MaassenVanDenBrink, A, Villalón, C M
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2006
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1629409/
https://ncbi.nlm.nih.gov/pubmed/16880765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706839
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