Dihydroergotamine inhibits the vasodepressor sensory CGRPergic outflow by prejunctional activation of α(2)-adrenoceptors and 5-HT(1) receptors

BACKGROUND: Dihydroergotamine (DHE) is an antimigraine drug that produces cranial vasoconstriction and inhibits trigeminal CGRP release; furthermore, it inhibits the vasodepressor sensory CGRPergic outflow, but the receptors involved remain unknown. Prejunctional activation of α(2A/2C)-adrenergic, s...

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Detalhes bibliográficos
Publicado no:J Headache Pain
Main Authors: González-Hernández, Abimael, Lozano-Cuenca, Jair, Marichal-Cancino, Bruno A., MaassenVanDenBrink, Antoinette, Villalón, Carlos M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Milan 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970131/
https://ncbi.nlm.nih.gov/pubmed/29802544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10194-018-0869-8
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