Binding Mode Characterization of 6α- and 6β-N-Heterocyclic Substituted Naltrexamine Derivatives via Docking in Opioid Receptor Crystal Structures and Site-directed Mutagenesis Studies: Application of the “Message–Address” Concept in Development of Mu Opioid Receptor Selective Antagonists

Highly selective opioid receptor antagonists are essential pharmacological probes in opioid receptor structural characterization and opioid agonist functional studies. Currently, there is no highly selective, non-peptidyl and reversible mu opioid receptor antagonist available. Among a series of nalt...

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Detalhes bibliográficos
Main Authors: Zaidi, Saheem A., Arnatt, Christopher K., He, Hengjun, Selley, Dana E., Mosier, Philip D., Kellogg, Glen E., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831368/
https://ncbi.nlm.nih.gov/pubmed/24055076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.08.042
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