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Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis

Neuroinflammatory diseases, such as multiple sclerosis (MS), result from aberrant leucocyte traffic into the central nervous system (CNS). To breach the specialized blood-brain barrier, activated leucocytes interact with CNS endothelial cells (EC) and activate a CD54-mediated signaling pathway contr...

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Detalhes bibliográficos
Main Authors: Greenwood, John, Walters, Claire E., Pryce, Gareth, Kanuga, Naheed, Beraud, Evelyne, Baker, David, Adamson, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831156/
https://ncbi.nlm.nih.gov/pubmed/12626426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.02-1014fje
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