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Divergent Regulation of Dihydrofolate Reductase Between Malaria Parasite and Human Host
For half a century, successful antifolate therapy against Plasmodium falciparum malaria has been attributed to host-parasite differences in drug binding to dihydrofolate reductase–thymidylate synthase (DHFR-TS). Selectivity may also arise through previously unappreciated differences in regulation of...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3830934/ https://ncbi.nlm.nih.gov/pubmed/11964483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1068274 |
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