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Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen – A cautionary tale in screening transgenic parasites

Ketotifen has recently been reported to inhibit the growth of both asexual and sexual malaria parasites. A parasite transporter, PfgABCG2, has been implicated in its mechanism of action. Human dihydrofolate reductase (hDHFR) is the most commonly used selectable marker to create transgenic Plasmodium...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Int J Parasitol Drugs Drug Resist
मुख्य लेखकों: Tran, Phuong N., Tate, Cameron J., Ridgway, Melanie C., Saliba, Kevin J., Kirk, Kiaran, Maier, Alexander G.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Elsevier 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050295/
https://ncbi.nlm.nih.gov/pubmed/27705841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2016.09.003
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