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Evidence of CYP3A Allosterism In Vivo: Analysis of Fluconazole and Midazolam Interaction
The allosteric effect of fluconazole (effector) on the formation of 1’-hydroxymidazolam (1’-OH-MDZ) and 4-hydroxymidazolam (4-OH-MDZ) from the CYP3A4/5 substrate, midazolam (MDZ), was examined in healthy volunteers. Following pre-treatment of fluconazole, AUC(4-OH)/AUC(MDZ) increased 35–62%, while A...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3830930/ https://ncbi.nlm.nih.gov/pubmed/22048224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.178 |
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