Increased HO-1 Levels Ameliorate Fatty Liver Development Through a Reduction of Heme and Recruitment of FGF21

OBJECTIVE: Obese leptin deficient (ob/ob) mice are a model of adiposity that displays increased levels of fat, glucose and liver lipids. Our hypothesis is that HO-1 overexpression ameliorates fatty liver development. DESIGN AND METHODS: Obese mice were administered cobalt protoporphyrin (CoPP) and s...

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Main Authors: Hinds, Terry D., Sodhi, Komal, Meadows, Charles, Fedorova, Larisa, Puri, Nitin, Kim, Dong Hyun, Peterson, Stephen J., Shapiro, Joseph, Abraham, Nader G., Kappas, Attallah
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3830593/
https://ncbi.nlm.nih.gov/pubmed/23839791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.20559
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