Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway

Insulin resistance, with adipose tissue dysfunction, is one of the hallmarks of metabolic syndrome. We have reported a metabolic syndrome-like phenotype in heme oxygenase (HO)-2 knockout mice, which presented with concurrent HO-1 deficiency and were amenable to rescue by an EET analog. Apo A-I mimet...

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Главные авторы: Cao, Jian, Puri, Nitin, Sodhi, Komal, Bellner, Lars, Abraham, Nader G., Kappas, Attallah
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi Publishing Corporation 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335301/
https://ncbi.nlm.nih.gov/pubmed/22577519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/628147
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