The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells

Chemoresistance of cancer cells has been a severe problem in multiple types of cancers. One possibility is to combine different drugs with chemotherapy for improved efficacy. Cyclopamine blocks Hedgehog signaling by antagonizing Smo function, which induces tumor apoptosis. Here, we show that the com...

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Hauptverfasser: Chai, Feng, Zhou, Jiangang, Chen, Cheng, Xie, Song, Chen, Xiao, Su, Ping, Shi, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2013
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829677/
https://ncbi.nlm.nih.gov/pubmed/24250231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S51914
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