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General Control Nonderepressible 2 (GCN2) Kinase Protects Oligodendrocytes and White Matter during Branched-chain Amino Acid Deficiency in Mice

Branched-chain amino acid (BCAA) catabolism is regulated by branched-chain α-keto acid dehydrogenase, an enzyme complex that is inhibited when phosphorylated by its kinase (BDK). Loss of BDK function in mice and humans causes BCAA deficiency and epilepsy with autistic features. In response to amino...

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Bibliografiske detaljer
Main Authors: She, Pengxiang, Bunpo, Piyawan, Cundiff, Judy K., Wek, Ronald C., Harris, Robert A., Anthony, Tracy G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829435/
https://ncbi.nlm.nih.gov/pubmed/24019515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.498469
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